Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through D-quality evidence.

Disclaimer

The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

Digestive Wellness

Peppermint Oil

0.1-0.3mL (or 200mg), three times per day1,2,3,4,5

• Significant reduction of abdominal pain and global symptoms, relative to placebo6

• Benefits no longer present two weeks after supplement cessation6

Search for Peppermint Oil in the Fullscript catalog.

Soluble Dietary Fiber

20-35g of long-chain, intermediate viscous, soluble and moderately fermentable dietary fiber7

• Safe and effective in improving global IBS symptoms, relative to placebo8

• Form of soluble fiber used is important, since short-chain soluble and highly fermentable dietary fiber can result in rapid gas production that can aggravate symptoms in patients with IBS8

Search for Fiber in the Fullscript catalog.

Probiotics

25-50 billion CFU, one to three times per day10

• Effective in reducing symptoms and severity score in patients with IBS10

• Specific strain recommendations remain to be concluded11,12

• Current recommendations suggest using an equal dosage of lactobacillus and bifidobacterium species12

Search for Probiotics in the Fullscript catalog.

L-Glutamine

0.25 g/kg of weight, once per day, minimum 14 days15,16

• Glutamine has shown to improve intestinal permeability13,14,15,16

• Acute glutamine administration has been linked to a decrease of gastro-intestinal symptoms and improvement in intestinal permeability in athletes competing in heat15

Search for L-Glutamine in the Fullscript catalog.

References 

1

C

https://www.ncbi.nlm.nih.gov/pubmed/11148527

2

C

https://www.ncbi.nlm.nih.gov/pubmed/389344

3

C

https://www.ncbi.nlm.nih.gov/pubmed/3061106

4

B

https://www.ncbi.nlm.nih.gov/pubmed/17420159

5

B

https://www.ncbi.nlm.nih.gov/pubmed/9430014

6

B

https://www.ncbi.nlm.nih.gov/pubmed/23416804

7

A

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548066/

8

A

https://www.ncbi.nlm.nih.gov/pubmed/25070054

9

A

https://www.ncbi.nlm.nih.gov/pubmed/27372289

10

A

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356930/

11

A

https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD010972.pub2/full?highlightAbstract=irritable%7Cprobiot%7Cbowel%7Cwithdrawn%7Cirrit%7Cprobiotics%7Cirritabl

12

A

https://www.ncbi.nlm.nih.gov/pubmed/25070051/

13

A

https://www.ncbi.nlm.nih.gov/pubmed/27440684

14

B

https://www.ncbi.nlm.nih.gov/pubmed/21463215

15

C

https://www.ncbi.nlm.nih.gov/pubmed/29058112

16

C

https://www.ncbi.nlm.nih.gov/pubmed/15019120