Fatty Liver Support

Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through D-quality evidence.

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Disclaimer

The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

Milk Thistle (Silybum marianum)

70-140mg, two to three times per day, minimum 12 weeks1

Compared to a controlled regimens, significant reduction of AST and ALT levels were observed1,2,3
Demonstrated decrease in transaminases of NASH patients, which led to a revival of liver function in NASH patients, hence improving prognosis and progression of liver cirrhosis1,2,3

Milk Thistle (Silybum marianum) in the Fullscript catalog.

Vitamin E

800 IU, once per day, minimum 2 years4

Compared to control, vitamin E was shown to be effective in reducing fibrosis, AST, ALT, ALP, steatosis and inflammation5
It has been shown that vitamin E is the therapeutic choice for NASH as it has properties as an anti-inflammatory, anti-apoptotic and antioxidant6

Vitamin E in the Fullscript catalog.

Artichoke (Cynara scolymus)

600mg, once per day, minimum 2 months7

Artichoke leaf extract has been shown to have beneficial effects on liver enzymes ALT and AST7
Symptoms associated with NASH have been shown to be alleviated by artichoke leaf extract in addition to improving lipid levels and liver enzymes8

Artichoke (Cynara scolymus) in the Fullscript catalog.

Turmeric (Curcuma longa)

500-1000mg, total per day, minimum 8 weeks10,11,12

As a result of its anti-inflammatory, anti-apoptotic, and antioxidant properties, turmeric (Curcuma longa) has been shown to improve enzyme levels and histology of the liver. For example, turmeric (Curcuma longa) increases lipid peroxyl radical scavenging, decreases COX2, and decreases caspases 9, 8, and 39,12
Reduction in ALT, AST and GGT levels was observed10,11,12

Turmeric (Curcuma longa) in the Fullscript catalog.