Neurological Support- Mood Health

Protocol development in integrative medicine is not typically a simple process. Individuals require individualized care, and what works for one patient may not work for another.

To establish these protocols, we first developed a Rating Scale that could be used to discern the rigor of evidence supporting a specific nutrient’s therapeutic effect.

The following protocols were developed using only A through D-quality evidence.

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Disclaimer

The Fullscript Integrative Medical Advisory team has developed or collected these protocols from practitioners and supplier partners to help health care practitioners make decisions when building treatment plans. By adding this protocol to your Fullscript template library, you understand and accept that the recommendations in the protocol are for initial guidance and may not be appropriate for every patient.

Neurological Support- Mood Health

St John’s Wort (Hypericum perforatum)

600mg, total per day of 0.3 % hypericin and 1-4 % hyperforin standardized formula, minimum 6 weeks2,4,5,6,7

Hypericum perforatum demonstrated similar efficacy to SSRIs including criteria like remission rate, Hamilton-Anxiety Scale and depressive symptoms in patients with mild to moderate depression1,2
Improvement in relapse rates, Hamilton-Anxiety Scale, Beck Depression Inventory time courses and greater over-all improvement (Clinical Global Impressions (CGI) scale) was observed. In addition, Hypericum perforatum demonstrated a potential for prophylactic effect in patients with chronic depression or depression alone5,6,7
Link to interaction white paper: Nutrient Interactions

Hypericum perforatum in the Fullscript catalog.

Omega fatty acids

930-1400mg EPA 200-750mg DHA, total per day, minimum 12 weeks11,12

Dietary n-3 polyunsaturated fatty acids (PUFAs) were shown to lower the risk of depression8,9,10
Increased levels of red blood cell EPA, DHA and ratio were correlated with improved remission rate12

Omega fatty acids in the Fullscript catalog.

Rhodiola (Rhodiola rosea)

340mg, total per day, minimum 6 weeks14,15

Cell response to stress was shown to be regulated by rhodiola, which in return, positively impacted overall mood13
Overall depression symptoms including insomnia, somatization and emotional instability were improved15
A decrease in the Hamilton-Anxiety Scale was observed with fewer adverse effects than sertraline14

Rhodiola rosea in the Fullscript catalog.